Induction of γ-Globin by Histone Deacetylase Inhibitors
نویسندگان
چکیده
منابع مشابه
Induction of g-Globin by Histone Deacetylase Inhibitors
http://bloodjournal.hematologylibrary.org/content/90/5/2075.full.html Updated information and services can be found at: (1174 articles) Red Cells Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at...
متن کاملInduction of human globin gene expression by histone deacetylase inhibitors
http://bloodjournal.hematologylibrary.org/content/103/2/701.full.html Updated information and services can be found at: (1174 articles) Red Cells (1086 articles) Gene Expression Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in ...
متن کاملRED CELLS Induction of human globin gene expression by histone deacetylase inhibitors
We investigated the induction of human globin gene activity by 3 classes of histone deacetylase inhibitors: amide analogues of trichostatin A, hydroxamic acid analogues of trapoxin, and scriptaid and its analogues. The screening consisted of measuring the effects of these compounds on and human gene promoter activity by using cultures of GM979 cells stably transfected with a construct containin...
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The histone deacetylase inhibitors (HDA-CIs) butyrate and trichostatin A activate gamma-globin expression via a p38 mitogen-activating protein kinase (MAPK)-dependent mechanism. We hypothesized that down-stream effectors of p38 MAPK, namely activating transcription factor-2 (ATF-2) and cyclic AMP response element (CRE) binding protein (CREB), are intimately involved in fetal hemoglobin inductio...
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In addition to being a part of the metabolic fatty acid fuel cycle, butyrate is also capable of inducing growth arrest in a variety of normal cell types and senescence-like phenotypes in gynecological cancer cells, inhibiting DNA synthesis and cell growth in colonic tumor cell lines, suppressing hTERT mRNA expression and telomerase activity in human prostate cancer cells, and inducing stem cell...
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ژورنال
عنوان ژورنال: Blood
سال: 1997
ISSN: 1528-0020,0006-4971
DOI: 10.1182/blood.v90.5.2075